منابع مشابه
Biology of vascular calcification in renal disease.
The high rates of atherosclerotic vascular disease in patients with end-stage renal disease (ESRD) cannot be fully explained by the excess of traditional risk factors. Interest has therefore arisen in the possible role of vascular calcification, which is increased in these patients and may effect plaque stability and have detrimental hemodynamic consequences. Considerable evidence has accumulat...
متن کاملGenetics of vascular calcification.
Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy. Together these data support that extracellular adenosine and pyrophosphate are essential components of the pathways in vascular disease. Arterial calcification by impairing blood flow and redu...
متن کاملMechanism of vascular calcification
In the early 1900s, cholesterol deposition in atherosclerosis was considered a passive, degenerative, inevitable and end-stage process of ageing. After decades of research, it is now recognized as an active, regulated, treatable and preventable disorder related to deposition and oxidation of lipoprotein components. Similarly, in the past few decades, vascular calcification also has been conside...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملEstrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification.
RATIONALE Arterial calcification and osteoporosis are associated in postmenopausal women. RANK (the receptor activator of nuclear factor kappaB), RANKL (RANK ligand), and osteoprotegerin are key proteins in bone metabolism and have been found at the site of aortic calcification. The role of these proteins in vasculature, as well as the contribution of estrogen to vascular calcification, is poor...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2009
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2009.07.002